"We evaluated the impact of previous flu vaccinations on IFN-γ production and A/H1N1/California/7/2009-specific Ab levels measured by SRH at study entry (Table 1). The analysis showed significantly lower levels of IFN-γ production in response to A/H1N1/Brisbane/59/2007, A/H1N1/Solomon Islands/3/2006 and B/Florida/4/2006 in blood from study participants who had previously received seasonal flu vaccination (during the period 2006 to spring 2009) and who did not receive the pdm flu vaccine, than in those without any seasonal flu (or pdm) vaccination during the same period (p ≤ 0.04). "
BMC Infect Dis. 2014; 14: 319.
Published online 2014 Jun 11. doi: 10.1186/1471-2334-14-319
Difference in immune response in vaccinated and unvaccinated Swedish individuals after the 2009 influenza pandemic
Isabelle Magalhaes Mikael Eriksson, Charlotte Linde, Rashid Muhammad, Lalit Rane, Aditya Ambati, Rebecca Axelsson-Robertson, Bahareh Khalaj, Nancy Alvarez-Corrales, Giulia Lapini, Emanuele Montomoli, Annika Linde, Nancy L Pedersen,3 and Markus Maeurer